Abstract：The protein phosphatase 2C family (PP2C ) , belonging the protein phosphatases, is a kind of importantly specific serine/threonine dephosphatase.Recent studies show that PP2C control a lot of critical cellular functions:proliferation, cell cycle arrest, senescence and programmed cell death, apoptosis and autophagy, showing potentially biological role in regulating immune response, aging, neurogenesis and tumorigenesis.Several dominant cellular signaling pathways controlled by PP2C gene subtypes were reviewed in this paper, such as mitogen-activated protein kinase (MAPK) , phosphatidylinositol 3-kinase (PI3K) -AKT, transforming growth factorβ (TGF-β) /Smads, transcription factor nuclear factor-κB (NF-κB) and DNA-damage response pathways, which offered new ways to clarify the molecular basis and regular mechanisms for those physiological and pathological processes.

　　Keyword：PP2C protein phosphatases; cell signaling pathways; MAPK; PI3K-AKT; TGF-β/Smads; NF-κB; DNA damage response;

　　PP2C蛋白磷酸酶, 又称金属依赖性蛋白磷酸酶 (metal-dependent protein phophatases, PPMs) , 可以对磷酸化的丝/苏氨酸残基特异性脱磷酸。该类蛋白磷酸酶对广谱磷酸酶抑制剂冈田酸不敏感, 其脱磷酸催化活性需依赖2价阳离子Mg2+和Mn2+。有趣的是, 在Mg2+存在的条件下, PP2Cδ磷酸酶活性被抑制而非激活[1]。

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